Hog (HDL on git): a collaborative HDL management tool

Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112

RATIONALE CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL). OBJECTIVE To explore the mechanisms by which the formation of small HDL particles is induced by CSL112. METHODS AND RESULTS Infusion of CSL112 into humans caused elevation of 2 small diameter HDL fractions and 1 large diameter...

HDL Cholesterol Story Is Dead: Long Live HDL!

It is a great irony that the earliest discovered lipoprotein is also the least well understood. In 1929, Michel Machebouef at the Pasteur Institute in Paris, using salt precipitation techniques, isolated a lipoprotein particle from horse serum composed predominantly of an a-globulin (59%), which we now know to be high-density lipoprotein (HDL) (1). Epidemiological studies in the 1970s, includin...

HDL Function: Redefining the HDL Hypothesis for the 21 Century

HDL as a treatment target.

Editor–in–Chief, The Journal of Clinical Lipidology, Charles Howard Candler Professor of Medicine Emeritus, Emory University School of Medicine, 1670 Clairmont Road, Atlanta, GA 30033, USA (Dr. Brown); Director of Lipoprotein and Atherosclerosis, Medstar Research Institute, Washington, DC, USA (Dr. Brewer); Professor of Medicine & Director of Preventive Cardiology & Lipid Clinic, University of ...

Basic Concepts for an HDL Reverse Engineering Tool - SetGunther